ACOG
From the American College of Obstetricians & Gynecologists
Menu

Many people with allergies take antihistamines for relief. Studies show that some over-the-counter (OTC) allergy medications are safe to use during pregnancy, including

  • chlorpheniramine

  • dexchlorpheniramine

Newer antihistamines, such as cetirizine and loratadine, may also be safe. And there is a corticosteroid nasal spray that is safe to use during pregnancy. But one of the most common OTC decongestants, pseudoephedrine, has been linked to a small risk of abdominal wall birth defects. Do not use pseudoephedrine during the first 3 months of pregnancy.

Check with your ob-gyn before taking any over-the-counter allergy medication.



About Ask ACOG

Do you have a question about women’s health? ACOG is here with answers to help you stay healthy. Browse all questions.

Go

Last updated: March 2025

Last reviewed: March 2025

Copyright 2026 by the American College of Obstetricians and Gynecologists. All rights reserved. Read copyright and permissions information.

This information is designed as an educational aid for the public. It offers current information and opinions related to women's health. It is not intended as a statement of the standard of care. It does not explain all of the proper treatments or methods of care. It is not a substitute for the advice of a physician. Read ACOG’s complete disclaimer.