What should I know about hormone shots and preterm birth?

Shots of a lab-made hormone (also called a progestin) used to be recommended to help prevent preterm birth. These shots were known by the brand name Makena and by the generic name 17-OHPC (17-alpha hydroxyprogesterone caproate). Makena and 17-OHPC have been removed from the market and are no longer available in the U.S.

If you are at risk of preterm birth, talk with your ob-gyn about other approved treatments that may help prevent it. Treatments may include cervical cerclage and vaginal progesterone.

It is possible that some doctors may still prescribe these hormone shots using compounding pharmacies. Compounding pharmacies make custom medications, called compounded medications. These medications are not regulated by the U.S Food and Drug Administration. They may vary in strength and purity, and they may not be covered by insurance. You should talk with your ob-gyn about the potential benefits and risks of using a compounding pharmacy for hormone shots.

Copyright 2024 by the American College of Obstetricians and Gynecologists. All rights reserved. Read copyright and permissions information.

This information is designed as an educational aid for the public. It offers current information and opinions related to health care. It is not intended as a statement of the standard of care. It does not explain all of the proper treatments or methods of care. It is not a substitute for the advice of a physician. Read ACOG’s complete disclaimer.